GLP-1 Drug Improved Motivation in Major Depressive Disorder
Treatment with oral semaglutide (Rybelsus) significantly improved motivation measures in patients with major depressive disorder (MDD), according to a secondary analysis of a randomized trial. Among 72 participants with MDD and overweight or obesity, those receiving oral semaglutide 14 mg showed an increased willingness to expend physical effort when higher expected rewards were present (treatment […]
Should Patients Over 75 Undergo Surveillance Colonoscopies?
Colorectal cancer prevention has been framed around a simple principle: find polyps early, remove them, and repeat colonoscopy to prevent cancer down the line. This approach has saved lives. But like many well-intentioned practices in medicine, what works well at one stage of life may offer diminishing, and even negligible, returns at another. Why We […]
GLP-1 Drugs Make Promising Debut in TAVR, Carotid Artery Stenting
Introducción Cardiovascular protection with GLP-1 receptor agonists may benefit patients undergoing certain transcatheter procedures, according to two observational studies. When used as an adjunct to transcatheter aortic valve replacement (TAVR), tirzepatide (Mounjaro, Zepbound) reduced heart failure (HF) events in the 1 year after the procedure, reported Ibrahim Mortada, MD, of the University of Texas Medical […]
FDA Expands Approval of Drug to Stave Off Type 1 Diabetes
Introducción The FDA has expanded the approval for teplizumab (Tzield), a biologic agent designed to delay the progression of preclinical type 1 diabetes to its symptomatic form, now including children as young as 1 year old, as announced by Sanofi on Wednesday. Picos de Diagnóstico The initial and most common peak for type 1 diabetes […]
Gaps in PrEP Use Among Youth at Risk for HIV
U.S. adolescents and young adults at risk of HIV aren’t getting the preexposure prophylaxis (PrEP) prescriptions they need, according to a national analysis of prescription data on over 100,000 youth. In individuals ages 13 to 21 years with a documented sexually transmitted infection (STI) or high-risk sexual behavior, just 1.6% filled a PrEP prescription from […]
ACIP’s Hep B Vaccine Recs Would Increase Deaths, Cancers, Studies Warn
Skipping the universal birth dose of the hepatitis B vaccine would cause preventable acute and chronic hepatitis B virus (HBV) infections, liver cancers, deaths, and add millions of dollars in additional healthcare costs, according to two modeling studies published in JAMA Pediatrics. The two studies’ cautionary predictions come in the wake of Health Secretary Robert […]
Diabetic ‘Dumped’ at Shelter; The Opioid Victims Getting $0; Clade I Mpox on Flights
Diabetic Patient Incident A CMS inspection report described how a diabetic patient with dementia at Eastland Healthcare and Rehabilitation Center in Ohio was subsequently “dumped” on the sidewalk of a homeless shelter. This alarming incident raises serious concerns about the standards of care in long-term facilities and the ethical responsibilities toward vulnerable individuals. Opioid Victims […]
COVID-19 at Time of Heart Attack Linked to Higher Mortality Risk
Hospitalized patients who had both ST-elevation myocardial infarction (STEMI) and COVID-19 had an excess risk of mortality, even after discharge, according to long-term results from a registry analysis. In a group of over 2,300 patients hospitalized with STEMI, the 1-year mortality rate was 45% in those who were also positive for COVID compared with 27% […]
FDA Staff Raises Concerns on Breast, Prostate Cancer Drug Applications
For the first time since last July the FDA’s Oncologic Drugs Advisory Committee (ODAC) will meet on Thursday to evaluate two cancer drugs after FDA staff voiced concerns about benefit-risk assessments, despite positive trial results. In a morning session, ODAC panelists will discuss a new drug application for the investigational oral selective estrogen receptor degrader […]
ACOG-endorsed guidance outlines key steps for managing cancer in pregnancy
New ACOG‑endorsed guidance from the Society for Maternal‑Fetal Medicine provides evidence‑based recommendations for diagnosing and managing cancer during pregnancy, now affecting about 1 in 1,000 pregnancies. Recommendations