SCCM 2026: Endotracheal surfactant shows limited benefit in severe infant bronchiolitis
In the multicenter, phase 2 BESS trial, 232 mechanically ventilated infants with life‑threatening bronchiolitis were randomized to endotracheal poractant alfa or a sham procedure, with the primary outcome being duration of invasive mechanical ventilation (IMV) from randomization to final successful extubation. Reported at the Society of Critical Care Medicine annual meeting and published in Lancet […]
Antibiotics during gut infections linked to higher IBS risk
This systematic review and meta-analysis evaluated 31 studies including 422,350 patients and found that antibiotic exposure was associated with a higher incidence of new-onset IBS. Overall, IBS developed in 26% of antibiotic users vs. 20% of non-users (incidence rate ratio [IRR], 1.30; 95% confidence interval [CI], 1.07–1.58; p=0.008). In sensitivity analyses limited to patients who […]
SCCM 2026: Sepsis tied to nearly 1 in 5 pediatric hospital deaths nationwide
Findings presented at the Society of Critical Care Medicine annual meeting show that, among 3.9 million pediatric hospitalizations across Epic Cosmos and HCA Healthcare systems, 1.3% met the Pediatric Sepsis Event (PSE) definition—representing 51,542 cases with a mean age of 6.6 years, 44.3% of whom were female. Most cases were community‑onset (72.6%), and 61.6% involved […]
Diet and common medications may curb recurrent kidney stones, but evidence remains limited
In a systematic review of 31 studies (mostly randomized trials), increased fluid intake; a diet with normal to high calcium, low protein, and low sodium; thiazide diuretics; alkali therapy; and allopurinol were associated with lower recurrence of calcium oxalate or calcium phosphate stones in adults, although strength of evidence was low. Selective, stone-based pharmacotherapy didn’t […]
Dementia Risk Rises After Severe Infection
Dementia risk rose after older adults had severe infection and the risk was not attributable to other comorbidities, a Finnish registry study suggested. Of all hospital-treated diseases recorded 20 years before a dementia diagnosis, 29 were robustly associated with increased dementia risk, said Pyry Sipilä, MD, PhD, of the University of Helsinki, and colleagues. Two […]
EULAR Updates Its Guidance on Managing Behcet’s Syndrome
Behçet’s syndrome poses some of the most difficult management challenges in all of rheumatology, but a newly updated guidelineopens in a new tab or window from the European Alliance of Associations for Rheumatology (EULAR) should help clinicians stay on top of the complexities. The new guideline, developed by Gulen Hatemi, MD, of Istanbul University, and […]
Epstein Autopsy Doc Speaks; Device Tied to Serious Injuries; Boston Singer Dies
Note that some links may require registration or subscription. Kristin Roman, MD, the doctor who performed the autopsy on sex offender Jeffrey Epstein, explains why she was hesitantopens in a new tab or window to declare his death a suicide. (Business Insider via MSN) Members of the CDC’s Advisory Committee on Immunization Practices (ACIP) have […]
Probiotic Supplementation and Metabolic–Immune Biomarkers: 12-Week RCT Findings
Investigators report a 12-week randomized, double-blind, placebo-controlled trial comparing a multi-strain probiotic with placebo in 39 adults with subthreshold depression, focusing on fasting metabolic indices and immune-related biomarkers. Over follow-up, the article describes between-group differences in trajectories for markers related to glucose regulation and incretin signaling, alongside circulating indicators commonly used to track metabolic endotoxemia […]
NGR1 Restores Mitochondrial Oxphos and Reduces Steatosis in a CDAFHD Mash Model
Using a choline-deficient, L-amino acid-defined high-fat diet (CDAHFD) mouse model of metabolic dysfunction–associated steatohepatitis (MASH), a recent study reports that notoginsenoside R1 (NGR1) lessened MASH-like liver changes. They present multi-omics and functional assays as consistent with upregulation of mitochondrial oxidative phosphorylation (OXPHOS) components and improved mitochondrial function. Evidence in the report spans liver biochemistry, gross […]
Bluechew Promises a Convenient Way to Get ED Medication, But Does it Work? [Bluechew Review 2020]
Bluechew. It sounds like a kids bubble gum, but it does something more serious for men. It’s Viagra ( sildenafil) or Cialis (tadalafil) in a chewable tablet, and it’s meant to give men their erections back. Around 5 percent of men in their 40’s have complete Erectile Dysfunction problems and 15 percent in their 70s. […]