Court Restricts Abortion Access Across U.S. by Blocking the Mailing of Mifepristone
Resumen del caso A federal appeals court has restricted access to one of the most common means of abortion in the U.S. by blocking the mailing of mifepristone prescriptions. The unanimous ruling Friday from a three-judge panel of the New Orleans-based 5th U.S. Circuit Court of Appeals requires that the abortion pill be distributed only […]
FDA Takes Steps to Expand Testosterone for Men’s Libido
Introducción Heralding a “step forward on testosterone therapy for men,” the FDA announced an initiative to support a potential new indication of low libido in men due to idiopathic hypogonadism. The FDA will encourage drug companies with existing approved indications for testosterone replacement therapy (TRT) to contact the agency about the potential new indication. “New […]
Novel Agent Reduces Seizures in Treatment-Resistant Epilepsy
Introducción Investigational azetukalner met its primary endpoint of reducing focal onset seizure frequency across two doses, initial findings from the phase III X-TOLE2 trial showed. Over 12 weeks, adjunctive treatment with 25 mg azetukalner led to a 53.2% median decline from baseline in monthly focal onset seizure frequency, compared with a 10.4% drop for placebo […]
Novel KRAS Drug Shows ‘Excellent’ Efficacy in Tough-to-Treat Lung Cancer
San Diego — Investigational zoldonrasib was well tolerated and showed encouraging clinical activity in previously treated KRAS G12D-mutated non-small cell lung cancer (NSCLC), according to a phase I study. Among patients previously treated with an immune checkpoint inhibitor and platinum-based chemotherapy (but not docetaxel), the objective response rate was 52%, with a disease control rate […]
GLP-1 Drug Improved Motivation in Major Depressive Disorder
Treatment with oral semaglutide (Rybelsus) significantly improved motivation measures in patients with major depressive disorder (MDD), according to a secondary analysis of a randomized trial. Among 72 participants with MDD and overweight or obesity, those receiving oral semaglutide 14 mg showed an increased willingness to expend physical effort when higher expected rewards were present (treatment […]
Should Patients Over 75 Undergo Surveillance Colonoscopies?
Colorectal cancer prevention has been framed around a simple principle: find polyps early, remove them, and repeat colonoscopy to prevent cancer down the line. This approach has saved lives. But like many well-intentioned practices in medicine, what works well at one stage of life may offer diminishing, and even negligible, returns at another. Why We […]
GLP-1 Drugs Make Promising Debut in TAVR, Carotid Artery Stenting
Introducción Cardiovascular protection with GLP-1 receptor agonists may benefit patients undergoing certain transcatheter procedures, according to two observational studies. When used as an adjunct to transcatheter aortic valve replacement (TAVR), tirzepatide (Mounjaro, Zepbound) reduced heart failure (HF) events in the 1 year after the procedure, reported Ibrahim Mortada, MD, of the University of Texas Medical […]
FDA Expands Approval of Drug to Stave Off Type 1 Diabetes
Introducción The FDA has expanded the approval for teplizumab (Tzield), a biologic agent designed to delay the progression of preclinical type 1 diabetes to its symptomatic form, now including children as young as 1 year old, as announced by Sanofi on Wednesday. Picos de Diagnóstico The initial and most common peak for type 1 diabetes […]
Gaps in PrEP Use Among Youth at Risk for HIV
U.S. adolescents and young adults at risk of HIV aren’t getting the preexposure prophylaxis (PrEP) prescriptions they need, according to a national analysis of prescription data on over 100,000 youth. In individuals ages 13 to 21 years with a documented sexually transmitted infection (STI) or high-risk sexual behavior, just 1.6% filled a PrEP prescription from […]
ACIP’s Hep B Vaccine Recs Would Increase Deaths, Cancers, Studies Warn
Skipping the universal birth dose of the hepatitis B vaccine would cause preventable acute and chronic hepatitis B virus (HBV) infections, liver cancers, deaths, and add millions of dollars in additional healthcare costs, according to two modeling studies published in JAMA Pediatrics. The two studies’ cautionary predictions come in the wake of Health Secretary Robert […]