Hospitalized patients who had both ST-elevation myocardial infarction (STEMI) and COVID-19 had an excess risk of mortality, even after discharge, according to long-term results from a registry analysis.
In a group of over 2,300 patients hospitalized with STEMI, the 1-year mortality rate was 45% in those who were also positive for COVID compared with 27% in those who tested negative and 11% of historical controls from 2018-2019, reported Payam Dehghani, MD, of Prairie Vascular Research in Regina, Saskatchewan, at the Society for Cardiovascular Angiography and Interventions (SCAI)opens in a new tab or window annual meeting in Montreal.
The study was simultaneously published in JSCAIopens in a new tab or window.
All-cause mortality was significantly higher in the COVID-positive group (HR 4.88, 95% CI 3.73-6.39, P<0.001) and the COVID-negative group (HR 3.93, 95% CI 2.92-5.29, P<0.001) compared with historical controls.
A majority of deaths (86%) occurred during the index hospitalization. Among survivors beyond hospitalization, the 1-year mortality rate was 12% in the COVID-positive group (HR 2.20, 95% CI 1.26-3.85, P=0.006), 9.6% in the COVID-negative group (HR 2.31, 95% CI 1.26-4.21, P=0.007), and 5.3% in historical controls (P<0.001).
Impact of COVID on Mortality
These findings suggest that the higher mortality observed in COVID-19-positive STEMI patients likely reflects both the system-level impact of the COVID-19 pandemic and a fundamentally different thrombo-inflammatory disease process.
Fuente: https://www.medpagetoday.com/meetingcoverage/scai/120992
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