Drug Sheds 28% of Weight; Universal T1D Screening? Lilly Accuses Church of Fraud

Pérdida de peso con retatrutide

Patients with obesity dropped a mean 28% of their body weight with a 12-mg dose of the investigational triple-receptor agonist retatrutide over 80 weeks in a phase III study, Eli Lilly announced. Nearly half had weight loss of 30% or greater, levels typically only seen with bariatric surgery.

Beneficio limitado de suplementos

There was little to no benefit from using calcium and/or vitamin D supplements to prevent fractures and falls, a systematic review and meta-analysis of 69 randomized trials found. (The BMJ)

Robo de sensores de Dexcom G7

Two lots of Dexcom G7 sensors originally designated as scrap and intended for destruction were stolen and sold by third parties, maker Dexcom warned.

Screening para diabetes tipo 1

Rates of early-stage type 1 diabetes (T1D) and progression to clinical diabetes were similar regardless of family history in a screening study of children in Germany, suggesting that screening could be considered beyond genetically at-risk populations. (JAMA)

Uso de medicamentos GLP-1 en trastornos alimentarios

Patients with anorexia, bulimia, and other eating disorders are taking GLP-1 medications, alarming doctors. (Washington Post)

Límite de pago para semaglutida

Maryland’s Prescription Drug Affordability Board voted to put an upper payment limit on semaglutide (Ozempic) for type 2 diabetes, which would save the state an estimated $5.8 million per year. (Maryland Matters)

Diabetes tipo 2 en adolescentes

Prevalence of type 2 diabetes among adolescents ages 10 to 17 was nearly fourfold higher in 2022-2024 compared with a 2017 estimate of youth ages 10 to 19. (JAMA Pediatrics)

Pérdida de peso en síndrome de Prader-Willi

Young patients with Prader-Willi syndrome initially achieved clinically relevant weight loss with laparoscopic sleeve gastrectomy, but long-term benefits were markedly attenuated versus non-syndromic peers. (Journal of Clinical Endocrinology & Metabolism)

Uso de hormonas tiroideas en infertilidad

Nearly half (47%) of American Association of Clinical Endocrinology members said in a survey that they would use thyroid hormones in female euthyroid patients with infertility and elevated thyroid antibodies. (AACE Endocrinology & Diabetes)

Riesgo psiquiátrico y tratamiento tiroideo

Meanwhile, levothyroxine plus adjunct liothyronine treatment was associated with an increased risk for any psychiatric morbidity in patients with autoimmune hypothyroidism, a Swedish cohort study found. (Journal of the Endocrine Society)

Impacto de la atención afirmativa de género

The Trump administration’s crackdown on gender-affirming care has affected adults as well as children. (NBC News)

Programa de manejo de peso en Carolina del Norte

A pilot, primary care-based weight management program at UNC Health aimed at eliminating barriers to obesity care has successfully scaled and expanded across North Carolina since its launch in 2019. (NEJM Catalyst)

Desinformación sobre menopausia

Pervasive misinformation about perimenopause on social media could put women at risk, The Guardian warned.

Demandas de Eli Lilly

Eli Lilly accused several bishops at a Pentecostal church of a fraud scheme involving $200 million in illegitimate rebates submitted for dulaglutide (Trulicity). (CNBC)

Dietas y aumento de peso durante la menopausia

Low-insulinemic and planetary health diets were linked with less weight gain during menopause in a prospective cohort study. (JAMA Network Open)

Disclaimer: Esta información no debe ser considerada un consejo médico. Siempre consulte a un profesional de la salud antes de tomar decisiones sobre tratamientos o medicamentos.

Fuente: https://www.medpagetoday.com/endocrinology/generalendocrinology/121434