Once-Weekly Drug Combo for Controlled HIV Matches Standard Daily Regimens
Introducción Switching to a weekly oral investigational regimen of islatravir and lenacapavir (Sunlenca) was just as effective as daily oral standard-of-care regimens in patients with virologically suppressed HIV, according to two phase III trials. Resultados del Estudio ISLEND-1 In the double-blind ISLEND-1 trial, 93.4% of patients who switched from once-daily, single-tablet bictegravir, emtricitabine, and tenofovir […]
FDA Licenses First Freeze-Dried Plasma Product
Introducción The FDA licensed Ezplaz, the first freeze-dried plasma product available to adults in need of transfusion, on Wednesday. Ezplaz is intended for patients who need plasma — such as those who are bleeding, need massive transfusion, or are bleeding while on warfarin — when conventional frozen plasma is not available. Origen y características del […]
Florida Investigates Fauci; Obesity Drug Trial Sparks Lawsuit; ‘Early Bird’ Dinners
Note that some links may require registration or subscription. Florida Attorney General James Uthmeier launched a state investigationopens in a new tab or window into Anthony Fauci, MD, over COVID claims. (Politico) Meanwhile, Florida health officials released new state guidanceopens in a new tab or window discouraging the use of psychiatric medications for children with […]
Cyclospora Boosts Fears That Deadlier Foodborne Outbreaks Are Ahead
Preocupación sobre futuros brotes de enfermedades alimentarias The next foodborne illness outbreak could be much worse. That’s the concern of food safety leaders across the U.S. who are raising alarms over federal cuts they say have made it harder to detect and stop the spread of foodborne illnesses, such as the recent outbreaks of Cyclospora, […]
Nicotine e-cigarettes as a smoking cessation option? New guidance weighs in
Clinical takeaway: Discuss nicotine e-cigarettes as one of several evidence-based pharmacologic options for adults who smoke, using shared decision-making to match treatment with patient preferences while emphasizing complete transition away from combustible cigarettes. New guidance from an international expert working group, published in JAMA, recommends that US clinicians routinely include nicotine e-cigarettes in discussions of […]
Bone Density Appears to Rebound in Transgender Youth After Puberty Blockers Are Done
Resumen del estudio Bone growth among transgender and gender-diverse adolescents slowed compared with peers during pubertal suppression, but partially recovered after starting gender-affirming hormone therapy, a systematic review and meta-analysis showed. Across 10 longitudinal studies involving 751 adolescents, absolute bone mineral density (BMD) remained stable during gonadotropin-releasing hormone agonist (GnRHa) therapy over mean durations up […]
Cardiac Arrest During Bar Exam and Recent Cardiology Developments
Cardiac Arrest Incident A woman suffered a cardiac arrest while taking the New York State bar exam. She is suing Hofstra University, claiming that CPR and an automated external defibrillator were not provided promptly by the staff. There are allegations that fellow test-takers were discouraged from seeking emergency help. Support for Cardiac Sonographers According to […]
ADA Reviewing Police Tussle; Obesity Trial Lawsuit; Retatrutide’s Early Access
The American Diabetes Associationopens in a new tab or window (ADA) asked for patience as its Audit and Governance Committee reviews the incident at this year’s annual meeting — when five prominent experts were removed by policeopens in a new tab or window — and prepares recommendations on the organization’s response. Once-weekly somapacitan (Sogroya) was […]
Pancreatic Cancer Vaccine Shows Interception Promise in High-Risk Patients
A peptide vaccine targeting KRAS mutations in pancreatic cancer showed preliminary evidence of activity in a small study of high-risk patients. The vaccine elicited KRAS-specific T-cell responses in 18 of 20 patients with mutations associated with pancreatic ductal adenocarcinoma (PDAC). Vaccine-induced T-cell clonotypes persisted for up to 2 years, and no patient developed pancreatic cancer […]
Longer Therapeutic Cooling Comes Up Short After Cardiac Arrest
Extra hours of therapeutic hypothermia after out-of-hospital cardiac arrest (OHCA) conferred no better neuroprotection, a randomized trial found. The ICECAP trialists intended to test a range of durations of therapeutic hypothermia, from 6 to 72 hours, and found it evident after the first 200 patients that there was no point cooling people for more than […]