Introducción
Primitive or regressive reflexes — known as frontal release signs — later in life were associated with increased dementia risk, a longitudinal study of cognitively normal older adults showed.
In adults with intact cognition, the presence of two or more frontal release signs was associated with a significantly higher risk of progressing to dementia over 7 years (HR 1.78, 95% CI 1.02-3.09), reported Lauren Bojarski, DO, MS, of West Virginia University in Morgantown, and colleagues in JAMA Network Open.
¿Qué son los signos de liberación frontal?
Frontal release signs are present in newborn children and gradually disappear as the brain matures in early life. They include the Myerson sign (an inability to resist blinking when repeatedly tapped between the eyebrows), and grasp, snout, rooting, and palmomental reflexes. Reappearing signs are associated with brain injury or neurodegeneration and can be seen in late-life dementia.
Impacto de los signos de liberación frontal en el diagnóstico
Signs of frontal release are easy to assess and traditionally have been considered part of a standard neurologic exam. While individual signs have shown relatively low sensitivity and specificity for detecting injury or degeneration, a meta-analysis of 29 studies found that people with dementia were up to 16 times more likely to exhibit frontal release signs, with the grasp reflex showing the strongest link.
Fuente: https://www.medpagetoday.com/neurology/dementia/121660
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