Estudio sobre NAC
N-acetylcysteine (NAC) treatment led to changes in functional connectivity and cerebral glucose metabolism in people with multiple sclerosis (MS), a small randomized trial suggested.
The study aimed to assess oxidative stress in MS after treatment with NAC, an antioxidant that increases brain glutathione. People with mild to moderate MS were randomized to either NAC plus standard of care, or to standard of care only (the control group).
Blood oxygen level dependent (BOLD) functional MRI (fMRI) showed significant connectivity alterations in the inferior frontal region, cerebellum, and parts of the temporal and parietal lobes in the NAC group compared with the control group, reported Sahar Darabi Monadi, MD, of Thomas Jefferson University in Philadelphia, at the American Society of Functional Neuroradiology meeting in Newport Beach, California.
Fluorodeoxyglucose (FDG) PET revealed that the NAC group had corresponding increases in cerebral glucose metabolism in several of these areas, including the inferior frontal and inferior temporal gyri. Self-reported improvements in cognition and attention correlated with these changes.
The findings were published in IBRO Neuroscience Reports.
Impact on Cognitive Impairment
Multiple sclerosis affects 2.8 million people worldwide, and 40 to 70% experience cognitive impairment, which is the result of both inflammation and oxidative stress. Yet, the majority of the approved treatments target only inflammation and almost none address oxidative stress, which is a key driver of neurodegeneration,
Fuente: https://www.medpagetoday.com/meetingcoverage/asfnr/123392
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