FDA Panel Backs New COVID Vaccines Aimed at Dominant Strain
Voto a favor del nuevo vacuna The FDA’s vaccine advisors voted 8 to 0, with one abstention, in favor of a monovalent XFG vaccine for COVID-19 shots for the 2026-2027 season. Discusión sobre la variante BA.3.2 The Vaccines and Related Biological Products Advisory Committee (VRBPAC) also discussed the need to target the long-simmering BA.3.2 variant, […]
Ultra-Low-Dose Immunotherapy May Benefit Cancer Patients in Low-Resource Countries
Introducción CHICAGO — Triple oral metronomic chemotherapy combined with ultra-low-dose immunotherapy (TMC-I) may be a promising first-line treatment for patients in low-resource countries with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), an open-label phase III trial suggested. Beneficios de la terapia TMC-I extended median overall survival (OS), the primary endpoint, to 10.3 […]
PCOS Was Rebranded As PMOS. We Have Reservations.
Introducción The name of a condition that affects between 6-10% of all reproductive-age women was recently changed from PCOS (polycystic ovary syndrome) to PMOS (polyendocrine metabolic ovarian syndrome) by an international consensus process. Preocupaciones sobre el cambio de nombre Though well-intentioned, we have reservations about this change. We are concerned that it might exacerbate diagnostic […]
Senators Clash Over Youth Gender Care Bans
As the Trump administration continues to target gender-affirming care for youth, the Senate Health, Education, Labor and Pensions (HELP) committee debated the issue in a hearing on Wednesday. Committee members heard testimony against and in support of such care, with some calling for a federal ban, and others questioning why they were even there when […]
NICU Babies More Likely to Miss Rotavirus Vax
Introducción For U.S. kids born after the rotavirus vaccine was introduced, recommendations against administration in the neonatal intensive care unit (NICU) appeared to be a strong barrier to getting immunized, researchers reported. Children most likely to not receive a first rotavirus vaccine dose included those with extremely preterm birth (OR 14.6, 95% CI 11.2-20.0), birth […]
Treatment delays worsen survival in early-onset colorectal cancer
Clinical takeaway: In patients under 50 with colorectal cancer, consider the interval from diagnosis to therapy as a modifiable risk. A language barrier may flag those patients most susceptible to delays. More colorectal cancer is turning up in patients well under screening age, where incidence has climbed about 3% per year over the past 15 […]
Investigational Drugs and Health Updates
Investigational Apitegromab Investigational apitegromab, a selective myostatin activation inhibitor, effectively preserved lean mass when combined with tirzepatide (Zepbound) in a randomized phase II trial, suggesting it could help fight “Ozempic butt.” (Nature Medicine, BBC News) Retatrutide Prescriptions The FDA hasn’t yet reviewed retatrutide for safety and effectiveness, but doctors are prescribing the investigational weight-loss drug […]
Primitive Reflexes May Predict Dementia
Introducción Primitive or regressive reflexes — known as frontal release signs — later in life were associated with increased dementia risk, a longitudinal study of cognitively normal older adults showed. In adults with intact cognition, the presence of two or more frontal release signs was associated with a significantly higher risk of progressing to dementia […]
New approach preserves lean mass during GLP-1 weight loss
Clinical Takeaway: Lean mass loss remains a concern during GLP-1- and GIP-based weight loss therapy, particularly for older adults and others at risk for sarcopenia. These early data suggest that targeted myostatin inhibition may help preserve muscle while maintaining the weight-loss benefits of tirzepatide, although effects on strength, function, and long-term outcomes remain unknown. Transformación […]
U.S. Guidelines Didn’t Feature Government-Commissioned Study Finding Drinking Risks
A study commissioned by President Joe Biden’s administration to investigate alcohol-related health harms was released independently on Tuesday, after President Donald Trump’s administration decided not to feature the researchers’ findings in new dietary guidelinesopens in a new tab or window as it faced pushback from the alcohol industry and a congressional committee. The findings of […]