Psilocybin plus therapy shows promise in cocaine use disorder
Clinical Takeaway: Psilocybin-assisted psychotherapy may emerge as a future option for cocaine use disorder, but the findings are early. Cocaine use disorder remains one of the few major substance use disorders without an approved pharmacotherapy, and psychosocial interventions have produced only modest gains. This trial tested whether a single dose of psilocybin combined with manualized […]
Bill O’Reilly’s Illness; Striking Nurses Asking for $200,000; FDA Warns Test Makers
Bill O’Reilly Conservative commentator Bill O’Reilly, 76, is taking a step back from his podcast to deal with an undisclosed illness. This highlights the importance of health awareness, especially for public figures who influence many. It is crucial for everyone, particularly those in the public eye, to prioritize their health. Nurses Strike in NYC The […]
Colonoscopy Trial Highlights Strengths, Weaknesses in Benefits
Overview of the Study Findings Updated findings from a European randomized trial continued to show that colonoscopy screening significantly reduced colorectal cancer (CRC) incidence, but its impact on CRC mortality was less clear. At 13 years of follow-up, the incidence of CRC was 1.46% among participants who underwent colonoscopy screening versus 1.80% in the no-screening […]
FDA clears expanded access for promising pancreatic cancer drug
FDA has issued a “safe to proceed” letter authorizing expanded access to the investigational pancreatic cancer therapy daraxonrasib for patients with previously treated metastatic pancreatic ductal adenocarcinoma. Daraxonrasib Overview Daraxonrasib, also known as RMC‑6236, is a RAS inhibitor designed to target mutant RAS proteins, which are present in most pancreatic cancer tumors. Expanded Access Program […]
Once-Weekly Oral Combo for HIV Maintains High Rates of Virologic Suppression
Estudio de combinación semanal A once-weekly oral combination of islatravir plus lenacapavir (Sunlenca) for HIV maintained similarly high rates of virologic suppression compared with standard daily oral treatment in an open-label phase II trial. In 104 virologically suppressed adults with HIV-1 on the daily oral regimen of bictegravir, emtricitabine, and tenofovir alafenamide, just one patient […]
Here’s What Medical Marijuana Can Do for Older Patients
Suppressing a Sneeze May Have Led to Cerebrospinal Fluid Leak
Suppressing a sneeze may have led to a spontaneous leak of cerebrospinal fluid (CSF) and air entering the skull of a woman with no history of trauma or surgery. A 45-year-old woman was referred to an otorhinolaryngology–head and neck surgery outpatient clinic after having mild holocephalic headaches for 3 months, which were somewhat alleviated when […]
Anxiety in primary care: SSRIs in, benzos out
Clinical takeaway: SSRIs and SNRIs remain first-line for anxiety disorders, while benzodiazepines should be reserved for short-term bridge use given dependence risk, particularly in older adults. Anxiety disorders are the most common psychiatric conditions in primary care, yet fewer than half of cases are detected and only about 40% of affected patients receive adequate treatment. […]
One Blood Marker Is Tied to Cognition and Mortality in People Who Live Past 100
NfL and Cognition Neurofilament light chain (NfL), a measure of neuronal injury, emerged as a key blood-based biomarker associated with both cognitive function and survival in centenarians, according to a Japanese cohort study. Higher plasma NfL levels correlated with lower cognitive scores on the Mini-Mental Status Examination (MMSE) after adjusting for potential confounders (β = […]
First Clinical Trial in MOGAD Meets Primary Endpoint
Introducción The interleukin-6 (IL-6) inhibitor satralizumab (Enspryng) met its primary endpoint in the phase III METEOROID trial of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Satralizumab reduced the risk of a new relapse by 68% compared with placebo (HR 0.32, 95% CI 0.15-0.70, P=0.0025) in adults and adolescents with MOGAD, reported Michael Levy, MD, PhD, of […]